The neighborhood that is home to the Hotel Mediolanum is located between the Central Railway Station and Porta Venezia. This means that the historic city center, financial and commercial district, or the main shopping areas are all within easy reach of the hotel. The Hotel Mediolanum is located at Via Mauro Macchi 1, and is only a one mile drive to the Linate Airport nearby.

All of the rooms in the Hotel Mediolanum are outfitted with satellite TV, wireless Internet access, marble bathrooms, minibars, personal safes, and even rooms with no carpeting for allergy sufferers.

A four star accommodation in the very heart of the city is what guests of the Hotel Mediolanum will find. Here they can enjoy a daily breakfast buffet in the private breakfast room, sip a cocktail or cappuccino in the friendly and casual bar, rely on the business service center for professional support or enjoy the modern fitness center as well.